Intraepithelial carcinoma (Bowen disease) - Intraepiteliálny Karcinóm (Bowenova Choroba)
☆ Vo výsledkoch Stiftung Warentest z Nemecka za rok 2022 bola spokojnosť spotrebiteľov s ModelDerm len o niečo nižšia ako s platenými telemedicínskymi konzultáciami.
Typický prípad ― Intraepiteliálny Karcinóm (Bowenova Choroba) (Intraepithelial carcinoma (Bowen disease)) môže byť nesprávne diagnostikovaný ako dlhotrvajúci, nesvrbiaci ekzém.
References
Bowen's disease (BD) je typ rakoviny kože, ktorý začína vo vonkajšej vrstve kože (epidermis) . Je bežnejší u belochov a často sa vyskytuje v oblastiach vystavených slnečnému žiareniu, ale môže sa objaviť aj inde. BD sa zvyčajne prejavuje ako jedna lézia. BD sa často považuje za varovný signál pred vznikom vážnejšieho typu rakoviny kože. Na diagnostiku BD sa lekári zvyčajne spoliehajú na vyšetrenie vzoriek tkaniva pod mikroskopom (biopsia) .
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease postihuje väčšinou bielych jedincov vo veku nad 60 rokov. Medzi kľúčové rizikové faktory patrí dlhodobé vystavovanie sa slnku, oslabený imunitný systém, expozícia arzénu a kožná infekcia HPV. Kmene HPV 16, 18, 34 a 48 sú spojené s Bowenovou chorobou v genitálnych oblastiach. Postihnutie HPV v negenitálnych prípadoch je menej jasné.
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
Zvyčajne sa javí ako erytematózna, šupinatá alebo chrumkavá oblasť kdekoľvek na tele. Najčastejšou lokalizáciou sú dolné končatiny.
Je liečiteľná rôznymi možnosťami liečby, ako je kryoterapia, kyretáž, kauterizácia, fotodynamická terapia alebo excízia lézie.
○ Diagnostika a liečba
#Dermoscopy
#Skin biopsy
#Mohs surgery
#Photodynamic therapy